Fig. 2 Effect of hydroxychloroquine and azithromycin association on SARS-CoV 2 replication. 2A. Delta Ct between 0 and 60 h post infection. Ordered axis represents the variation of delta cycle-thresholds obtained by RT-PCR between H0 and H60 for each condition. Each point represents data obtained for one well. Number of replicates was indicated for each conditions are A10H5 n = 16, A10H2 n = 5, A10H1 n = 5, A5H5 n = 15, A5H2 n = 5, A5H1 n = 3, A2H5 n = 3, A2H2 n = 3, A2H1 n = 3 and n = 13 for the positive control. Median and interquartile range were indicated for each condition. *** represent significant results under p < 0,0005. Others are not significant compared to the control. 2B. Percentage of inhibition as compared to control by the combinations of 5 μM of hydroxychloroquine associated with 5 or 10 μM for azithromycin. Data represent the mean ± SD, representing three independent experiments conducted at least in triplicate. Source: Andreani et al., 2020.

Combined hydroxychloroquine and azithromycin show synergistic effect on SARS-CoV-2 in monkey Vero E6 cells in vitro but may not be effective in human alveoli, pneumocytes and other cells.

The cell types in which hydroxychloroquine is apparently ineffective include epithelial cells lining the nose, trachea, and distal airways, including alveoli and type II pneumocytes. However, it is useful to know that hydroxychloroquine and azithromycin have a synergistic effect in the cell types where SARS-CoV-2 infection and replication is dependent on endosomal pH.

French infectious disease specialist Didier Raoult presented a rapport to the French Senate in 2012 and talked about flu, SARS, antibiotics and viral infections.

Raoult on flu, antibiotics and viral infections in the French Senate in 2012.

We made a note of several interesting remarks that Didier Raoult, professor of microbiology and infectious disease, made in a presentation to members of the French Senate in 2012.

ACE2 expression in organs and systems most frequently implicated in COVID-19 complications. The gastrointestinal tract, kidneys and testis have the highest ACE2 expressions. In some organs, different cell types have remarkably distinct expressions, e.g. in the lungs, alveolar epithelial cells have higher ACE2 expression levels than bronchial epithelial cells; in the liver, ACE2 is not expressed in hepatocytes, Kupffer cells nor endothelial cells, but is detected in cholangiocytes, which canexplain liver injury to some extent. Furthermore, ACE2 expression is enriched on enterocytes of the small intestine compared to the colon. ACE2, angiotensin-converting enzyme 2; BNP, B-type natriuretic peptide; CRP, C- reactive protein; IL, interleukin; N/L, neutrophil-to-lymphocyte ratio; PT, prothrombin time; aPTT, activated partial thromboplastin time. Source: Vabret, 2020.

ACE2 expression in organs and systems most frequently affected in COVID-19.

The gastrointestinal tract, kidneys and testis have the highest ACE2 expressions.

Fauci, a strange 79 years old character, who has been involved in sabotage for over 30 years, suddenly warns about a real concern: vaccines often cause antibody-dependent enhancement (ADE) of the infection.

Fauci, a strange 79 years old character, who has been involved in sabotage for over 30 years, suddenly warns COVID-19 vaccines can be dangerous.

Use this video with Fauci to influence brainwashed sheep. The main danger today is if bureaucracy makes it compulsory to get vaccinated with ineffective and unsafe vaccines.

Didier Raoult, the head of a center for infectious disease in Marseille, France, on the current "standards of care" for the treatment of COVID-19: "you can't tell COVID-19 patients "stay at home, and when you can't breathe anymore, come to the hospital to die".

The current “standards of care” for the treatment of COVID-19: “stay at home, and when you can’t breathe anymore, come to the hospital to die”.

Didier Raoult, who is the head of a center for infectious disease in Marseille, France, summed up what is de facto “the standards of care” for COVID-19.

China may be telling the truth about the low number of COVID-19 cases: scientists there struggled to recruit patients for their studies.

The most interesting detail is the following sentence. Huang et al., 2020 (1): “The epidemic in Guangdong had been brought under control rapidly during the study making it difficult to recruit patients as planned.”

Mediterrannee Infections is a large infectious disease hospital network in the area of the city of Marseille.

Didier Raoult: “We did not test antibiotics against viruses. Now we do and we realize that a lot of antibiotics are effective against viruses.”

The notion that antibiotics are not effective against viruses has been pounded a lot. However, this notion may not be true.

The New Neander's Medical on December 14, 2020: Astra Zeneca's large trial gives us an idea of what percentage of SARS-CoV-2 infections are asymptomatic. In the control arm of COV002 group that did weekly swabs, the proportion of asymptomatic cases was 1.2%/(1.2%+1.8%)=40%.

What proportion of SARS-CoV-2 infections are asymptomatic?

Asympotomatic SARS-CoV-2 infections accounted for 40% of all SARS-CoV-2 infections in the control arm of Astra Zeneca-Oxford vaccine trial that did weekly swabs.

Ethnicity does NOT affect the risks in COVID-19. Vitamin D status may not either.

A study reported the same proportions of SARS-CoV-2-positive among different ethnicities in a Boston homeless shelter. Almost all the SARS-CoV-2-positive were “asymptomatic”.

Principles And Practice of Mechanical Ventilation, Third Edition (Tobin, Principles and Practice of Mechanical Ventilation) by Martin J. Tobin.

Physiological Literacy on mechanical ventilation in COVID-19: “Only a small proportion of patients—largely those in a cardiac arrest situation—“require” mechanical ventilation.”

Pulmonologist Michael J. Tobin: “Once a patient is placed on a ventilator, the key challenge is to avoid complications.
Mechanical ventilation (in and of itself) does not produce lung healing—it merely keeps patients alive until their own biological mechanisms are able to outwit the coronavirus.
The best way to minimize ventilator-associated complications is to avoid intubation unless it is absolutely necessary.
The surest way to increase Covid-19 mortality is liberal use of intubation and mechanical ventilation.