Nose warming.

This post is a piece of food for thought, mainly in the form of images. This post should stimulate your thinking. This post is also a test of Pattern recognition.

Dr. Paul Mason, a frequent guest at different low carb conferences and low carb podcasts, makes gross errors during all of his public appearances. His errors actually go beyond "gross" and are often frankly idiotic.

Another load of absurdities from the strange doctor Paul Mason.

People are strange. Many get confused even about the very basics of their trade or of whatever they are actively studying.
Grassroots health evolved towards a form of irresponsible primitivism: a group of confused individuals tours podcasts and health conferences and repeats the same absurdities at each appearance.

Principles And Practice of Mechanical Ventilation, Third Edition (Tobin, Principles and Practice of Mechanical Ventilation) by Martin J. Tobin.

Physiological Literacy on mechanical ventilation in COVID-19: “Only a small proportion of patients—largely those in a cardiac arrest situation—“require” mechanical ventilation.”

Pulmonologist Michael J. Tobin: “Once a patient is placed on a ventilator, the key challenge is to avoid complications.
Mechanical ventilation (in and of itself) does not produce lung healing—it merely keeps patients alive until their own biological mechanisms are able to outwit the coronavirus.
The best way to minimize ventilator-associated complications is to avoid intubation unless it is absolutely necessary.
The surest way to increase Covid-19 mortality is liberal use of intubation and mechanical ventilation.

T-cell response to respiratory virus infections.

Physiological Literacy.
The group of Stanley Perlman (1) did a good job in terms of clarity in their description of the role of T-cell mediated immune response to coronavirus infections.

Recently Discovered Human Coronaviruses - an article by Wevers and van der Hoek.

Viruses use peptide expressed on cellular membrane as “receptors” to enter host cells and then downregulate the expression of these peptides. SARS-CoV-1,2 and ACE2.

Physiological Literacy:
Brigitte A. Wevers, Lia van der Hoek, two researchers from the Netherlands, did a good job in describing how common coronaviruses penetrate host cells and some possible mechanisms of their pathological action.

Modlin, Sachs, 1998 (2): the average diurnal pH in the empty human stomach is around 1.5.

“Acid Related Diseases—Biology and Treatment” by I.M. Modlin, G. Sachs.

A book review.

Feel good about your blood pressure.

If your blood pressure is within the optimal range when you measure it, you will feel good each time you do it. Because you are taking care of your health, you are smart, you are healthy. You have a lot of reasons to feel a little bit better and to be in a better mood during your day.
Blood pressure, an extremely important biomarker, can be improved without medication in a majority of cases.

Figure 4 |Three modes of adaptation and maintenance of tissue homeostasis. The state of a tissue can range from basal, to stressed or malfunctioning, to damaged or infected, and each state is graded (as indicated by shading). The state affects the mode of maintenance of tissue homeostasis or adaptive responsethat is engaged by tissue-resident macrophages and, in some tissues, by other types of leukocyte. Blue arrows indicate signals that report the tissue state to macrophages; red arrows indicate macrophage-derived signals thatcontrol tissue adaptation. At one extreme of the range of responses is inflammation, which follows infection or tissue damage. By contrast, tissue stress or malfunction induces parainflammation, which helps a tissue to adapt to the noxious conditions and restore tissue functionality. Dysregulated para-inflammation might be responsible for the chronic inflammatory states that are associated with many modern human diseases, such as type 2 diabetes and atherosclerosis. Source: Medzhitov, 2008.

Physiological and pathological outcomes of inflammation.

Depending on the trigger, the inflammatory response has a different physiological purpose and pathological consequences. Of the three possible initiating stimuli, only infection-induced inflammation is coupled with the induction of an immune response.

Schematic representation of the pathway of the biogenesis of HDL.

An informative diagram, which is, in fact, a piece of Physiological Literacy.

FIG. 1. Schematic representation of the cycle of iron delivery to cells by transferrin, showing the uptake of diferric transferrin by cell receptors, internalization, release of iron at the lower intracellular pH, and recycling and release of apotransferrin.

Transferrin and lactoferrin.

This post is a work in progress. Last review and update: January 31, 2020. A short summary. This article contains … More