A Test: Do postprandial triglycerides always rise after a high-fat meal?

Fig. 3. Separation of TRL apolipoproteins by gradient (4-22.5%) polyacrylamide gel electrophoresis. The gels for three subjects, with increasing magnitude of postprandial triglyceridemia, are shown in the three panels. Postprandial changes in TRL triglyceride concentration are shown in the graphs at the bottom of each panel. The five lanes on each gel correspond (from left to right) to TRL fractions isolated at 0, 3, 6, 9, and 12 hr after the ingestion of the fat-rich meal. Panel A: Fractions from 25-year-old female; total postprandial plasma triglyceridemia - 894 mg - hr/dl. Panel B: Fractions from 65-year-old female; total postprandial plasma triglyceridemia - 1578 mg - hr/dl. Panel C: Fractions from 25-year-old male; total postprandial plasma triglyceridemia - 3224 mg * hr/dl. The apolipoprotein bands are identified at the left of each gel. Alb., albumin. Source: Cohn, 1988.

A Test of Physiological Literacy.

On the graphs and in tables from the study by Cohn et al., 1988 (1), we can observe the postprandial dynamics of some blood lipids and lipoproteins. The composition of the high-fat meal is in the citation below. The question:

1. Do postprandial triglycerides always rise after a high-fat meal?

The “fat meal” contained 33.3% fat, 33.3% protein, and 33.3% carbohydrate (by weight). Cohn et al., 1988 (6):

After a 14-hr overnight fast, subjects were given a fat meal, containing 1.0 g of fat/kg body weight and 7.0 mg of cholesterol/kg (given as egg yolk powder). The fat was given as soybean oil to 12 sub- jects and as soybean oil plus cream (l:l, w/w) to the remaining 10 subjects. Since no differences were observed between subjects fed the two fat mixtures, data were ana- lyzed together for all 22 subjects. The amount of fat given was designed to be %-% of that which an average Ameri- can ingests per day. The meal was prepared as a formula milkshake with added flavoring. Polycose and egg white protein were added to the formula so that the meal contained 33.3% fat, 33.3% protein, and 33.3% carbohydrate (by weight) or 53% fat, 23.5% protein, 23.5% carbohy- drate (by energy).

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