Monastyrsky’s probiotic supplement.

Monastyrsky's probiotic blend. Source: The website of Konstantin Monastyrsky.

Researcher and author Konstantin Monastyrsky.

Researcher and author Konstantin Monastyrsky
Researcher and author Konstantin Monastyrsky

Researcher and author Konstantin Monastyrsky did a lot of interesting work. Like most of the independent researchers, Monastyrsky occasionally makes errors or questionable recommendations. His work, however, is of interest.

Below, there is a list of ingredients of Konstantin Monastyrsky’s probiotic supplement. The list may give you some additional ideas for your experiments with probiotics.

Monastyrsky’s probiotic supplement.

Monastyrsky's probiotic blend. Source: The website of Konstantin Monastyrsky.
Monastyrsky’s probiotic blend. Source: The website of Konstantin Monastyrsky.

Lactobacillus acidophilus (DDS-1)4.3 Billion CFU
Lactobacillus rhamnosus (Lr-32)4.3 Billion CFU
Bifidobacterium lactis (HN019)1.9 Billion CFU
Lactococcus lactis (Ll-23)1.0 Billion CFU
Bifidobacterium longum (Bl-05)1.0 Billion CFU
Bifidobacterium bifidum/lactis (Bb-02)1.0 Billion CFU
Lactobacillus gasserri (Lg-36)1.0 Billion CFU
Streptococcus thermophilus (St-21)0.5 Billion CFU
Digestive and Prebiotic Blend FOS (fructooligosaccharides) and Ulmus fulva (bark).210 mg

Deconstruction of Monastyrsky’s recommendations.

Konstantin Monastyrsky:

How to take Enterophilus

The rules are reasonable, based on the “nature of the beasts” and common sense:

Take probiotic formulas in the morning, on an empty stomach, so they are exposed to the least amount of acidity and enzymes in the stomach and upper intestines. You can take Enterophilus with Hydro-C and GI Recovery.

Don’t take bacterial supplements while taking antibiotics because the latter will kill them anyway, and they may render antibiotics somewhat less efficient against its intended target.

Stomach pH and probiotics.

Monastyrsky recommends taking his probiotic supplement early in the morning on an empty stomach. Many other practitioners and researchers recommend the same. There is, however, a problem with this recommendation. Indeed, if we look at the table from a 2019 study by Surofchy, we can see that about half of the subjects have a stomach pH of less than 1. The mean pH for all the subjects was 0.75, that is, very low.

Baseline stomach pH in healthy subjects can be as low as 0.5. The mean of all nine healthy subjects was 0.75. Source: Surofchy, 2019 (3).
Baseline stomach pH in healthy subjects can be as low as 0.5. The mean of all nine healthy subjects was 0.75. Source: Surofchy, 2019 (3).

The lowest pH observed among the 9 subjects in the study by Surfochy (the table above) was 0.5. This pH is very low and will be challenging for any acid-resistant probiotic. But even the mean pH of 0.75 is quite challenging for many probiotics. In the graph from a 2008 study by Graff et al., we can see how the viability of a probiotic yeast Saccharomyces boulardii drops at a pH of 1.

Viability of freez-dried S. boulardii in HCL at pH 1, 2, 3 and 4. Source: Graff, 2008.
Viability of freez-dried S. boulardii in HCL at pH 1, 2, 3 and 4. Source: Graff, 2008.

The probiotic supplement of Monastyrsky does not contain yeasts. But it may still be challenging for some probiotic bacteria to withstand very low pH that is quite apparently common.

Should probiotics and antibiotics be taken at the same time?

Monastyrsky recommends against taking probiotics and antibiotics at the same time. This recommendation is questionable. In the published literature, there are studies that showed that simultaneous intake of probiotics and antibiotics can produce better results than antibiotics alone. The figure below shows how simultaneous treatment with both antibiotics and a probiotic yeast protected microbial population in the intestine.

Figure 2 Generalized scheme of the effects of antibiotic dysbiosis on habitual/essential bacteria and other substantial bacteria. Notes: Upon a 2-week antibiotic treatment (red area), the main microbial population suffers an abrupt decrease (blue line). Saccharomyces boulardii administered during antibiotic treatment (red area; red line) can reduce this decline by protecting the microbiota. If instead S. boulardii is administered following antibiotic treatment (green area; green line), S. boulardii can support a faster regeneration of the microbial population. Accordingly, the optimum would be a combination of both, a treatment with S. boulardii during and following antibiotic treatment. This is represented by the hypothetical black dotted line, which was derived from the other lines. The worst-case scenario is no S. boulardii treatment (blue line). Pioneer bacteria and accidental bacteria are excluded. Source: More and Swidsinski, 2015.
Figure 2 Generalized scheme of the effects of antibiotic dysbiosis on habitual/essential bacteria and other substantial bacteria. Notes: Upon a 2-week antibiotic treatment (red area), the main microbial population suffers an abrupt decrease (blue line). Saccharomyces boulardii administered during antibiotic treatment (red area; red line) can reduce this decline by protecting the microbiota. If instead S. boulardii is administered following antibiotic treatment (green area; green line), S. boulardii can support a faster regeneration of the microbial population. Accordingly, the optimum would be a combination of both, a treatment with S. boulardii during and following antibiotic treatment. This is represented by the hypothetical black dotted line, which was derived from the other lines. The worst-case scenario is no S. boulardii treatment (blue line). Pioneer bacteria and accidental bacteria are excluded. Source: More and Swidsinski, 2015.

Conclusions:

Consider strains from the product designed by researcher Konstantin Monastyrsky for your experiments with probiotics. Remain critical and cautious to recommendations of different researchers and health educators.

If you need help with using probiotics to improve your gut health, do not hesitate to get in contact with us. After a lot of trials and errors, we have developed some “protocols” that may work for you.

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