We made a note of several interesting remarks that Didier Raoult, professor of microbiology and infectious disease, made in a presentation to members of the French Senate in 2012.
Tag: SARS(2002-2004)
Corticosteroid administration depletes lymphocytes and increases neutrophils in peripheral circulation.
Administration of exogenous corticosteroids to COVID-19 patients should, therefore, further increase neutrophils to leukocytes ratio (NLR). If higher NLR is associated with poor outcomes in COVID-19, administration of corticosteroids would seem counterproductive. Are steroids used appropriately in the treatment of COVID-19?
There is an antibody-dependent enhancement (ADE) of SARS-CoV-1 infection. Notably, some vaccines enhance infection.
Some vaccines against animal coronaviruses have been successfully generated, but their development has proven very difficult due to immune enhancement of disease in vaccinated recipients (28, 53, 65).