Twenty-four-hour serum TSH concentration time series in 24 healthy men and 22 healthy women. Blood samples were taken every 10 minutes for 24 hours. Blood sampling started at 9AM. Lights were off between 11PMand 7:30AM. Data are shown as the group mean and SEM. [Reproduced from F. Roelfsema et al: Thyrotropin secretion profiles are not different in men and women.J Clin Endocrinol Metab. 2009.

Low TSH and osteoporosis.

Prolonged fasting diminishes thyroid-stimulating hormone (TSH) secretion by reducing burst amplitude and by blunting the nocturnal increase. It is recognized that TSH plays a role in maintaining bone health. If following a restrictive diet results in the suppression of the nocturnal rise in TSH and diminished burst of the hormone, it may be detrimental to bone health.

Physiological Literacy: Mice did not evolve to survive more than one day of fasting.

Low-carb high-fat diet (LCHF) dangerously resembles the “high-fat diet” that induces disease and chronic inflammation in mice.

Low-carb high-fat diet (LCHF) dangerously resembles the “high-fat diet” that induces disease and chronic inflammation in mice (as % of calories): 20% from protein (=99% casein), 20% from carbs (=maltodextrin, some sucrose), 60% from fat (=90% lard), and some fiber, vitamins, minerals. The dangerous resemblance between the “unhealthy” high-fat diet for laboratory rodents and “LCHF” is something to keep in mind.