Candida fungi, one of the likely culprits of your digestive troubles.

The text below contains several of the notes that we took while researching dysbiosis.

A hypothesis to explore: Inhibition of amylase by Candida and other pathogens.

A hypothesis to explore: Is it why half of the planet can’t digest starches? Inhibition of amylase by Candida and other pathogens:

SIBO? A bacteria produces a metabolite that inhibits alpha-amylase and thus the digestion of starches:
“Acarbose is a complex oligosaccharide obtained through fermentation by Actinoplanesutahensis. It is an inhibitor of pancreatic alpha-amylase”
Charmot D. 2012 (1).

1/n
Factoid:

“high Candida abundance was most strongly associated with the recent consumption of carbohydrates. Methanobrevibacter abundance was associated with both long term and recent consumption of carbohydrates”.

Factoid: "high Candida abundance was most strongly associated with the recent consumption of carbohydrates. Methobrevibacter abundance was associated with both long term and recent consumption of carbohydrates". — Factoid: “high Candida abundance was most strongly associated with the recent consumption of carbohydrates. Methanobrevibacter abundance was associated with both long term and recent consumption of carbohydrates”.

2/n

“Volunteers were screened to have a normal bowel frequency (minimum once every 2 days, maximum 3 times per day)”.

Analysis:
Normal stool frequency is once or twice a day, with a well-formed stool (cf. Bristol Stool Chart).

2/n "Volunteers were screened to have a normal bowel frequency (minimum once every 2 days, maximum 3 times per day)". Analysis: Normal stool frequency is once or twice a day, with a well-formed stool (cf. Bristol Stool Chart). — 2/n “Volunteers were screened to have a normal bowel frequency (minimum once every 2 days, maximum 3 times per day)”. Analysis: Normal stool frequency is once or twice a day, with a well-formed stool (cf. Bristol Stool Chart).

3/n

“The most prevalent genus in this sample set was Saccharomyces (present in 89% of the samples), followed by Candida (57%) and Cladosporium (42%).”

Microscopic image (200-fold magnification) of Candida albicans ATCC 10231, grown on cornmeal agar medium.

Scientific classification of Candida albicans (in English):

Kingdom: Fungi

Division: Ascomycota

Class: Saccharomycetes

Order: Saccharomycetales

Family: Saccharomycetaceae

Genus: Candida

Species: C. albicans

Classification of Candida albicans (in French) by Berkhout, 1923:

Règne: Fungi

Division: Ascomycota

Classe: Saccharomycetes

Ordre: Saccharomycetales

Famille: Saccharomycetaceae

Genre: Candida

Espèce: Candida albicans

Below, there is another image from a 2017 study by Guisbier et al. The authors inhibited Candida albicans with nanoparticles of selenium. “By 50%”.

This little factoid has limited practical use. The inhibition of 50% is relatively unimpressive. And it is not known what nanoparticles of selenium may do to normal human cells.

Candida and selenium nanoparticles. UV-visible spectra of the selenium colloidal solution at different irradiation times. The absorbance occurs mainly below ~600 nm and increases with irradiation time. b) Size distribution of the selenium colloidal solution obtained by Dynamic Light Scattering for different irradiation times. Inset: mean size versus the irradiation time. Inset: Photo of the colloidal solution after 1h irradiation. Source: Guisbliers, 2017.

Selected references:

1. Charmot D. Curr Pharm Des. 2012;18(10):1434-45.

2. Guisbiers et al., Nanomedicine. 2017 Apr;13(3):1095-1103.

A hypothesis to explore: Inhibition of amylase by Candida and other pathogens.

Scientific classification of Candida albicans (in English):

Classification of Candida albicans (in French) by Berkhout, 1923:

Selected references:

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